{"id":6836,"date":"2018-06-24T14:34:35","date_gmt":"2018-06-24T14:34:35","guid":{"rendered":"https:\/\/rc-inrikes.com\/shop\/?post_type=product&p=6836"},"modified":"2025-04-12T01:52:52","modified_gmt":"2025-04-12T01:52:52","slug":"tianeptin-e-tabletter-0-20mg","status":"publish","type":"product","link":"https:\/\/rc-inrikes.com\/shop\/product\/tianeptin-e-tabletter-0-20mg\/","title":{"rendered":"Tianeptin\/e Tabletter 0.20mg"},"content":{"rendered":"

Tianeptin<\/b> (varum\u00e4rkena Stablon, Coaxil, Tatinol, Tianeurax och Salymbra) \u00e4r en medicin som anv\u00e4nds prim\u00e4rt i behandlingen av kronisk depression. Den har dock visat p\u00e5 potential som behandling av astma och IBS \u2013 k\u00e4nslig tarm. Kemiskt sett s\u00e5 \u00e4r den n\u00e4ra besl\u00e4ktad med tricykliska antidepressiva<\/a> (TCA), men dess farmakologiska egenskaper \u00e4r n\u00e4rmast helt atypiska i j\u00e4mf\u00f6relse med TCA-preparaten \u2013 nyare forskning tyder p\u00e5 att Tianeptin verkar antidepressivt genom indirekt f\u00f6r\u00e4ndring av glutamaterg aktivitet (p\u00e5 AMPA och NMDA -receptorerna) och genom frig\u00f6relse av BDNF, som i sin tur p\u00e5verkar neuroplasticitet. [<\/span>1]<\/span><\/a><\/sup>[<\/span>2]<\/span><\/a><\/sup>[<\/span>3]<\/span><\/a><\/sup>[<\/span>4]<\/span><\/a><\/sup>[<\/span>5]<\/span><\/a><\/sup>[<\/span>6]<\/span><\/a><\/sup><\/p>\n

Det fullst\u00e4ndiga systematiska namnet<\/a> f\u00f6r substansen \u00e4r 7-[(3-kloro-6-metyl-5,5-dioxo-11H-benzo[c][2,1]benzotiazepin-11-yl)amino]heptanoisk syra.<\/p>\n

Tianeptin har antidepressiva och anxiolytiska (\u00e5ngestd\u00e4mpande) egenskaper[<\/span>7]<\/span><\/a><\/sup> utan n\u00e5gra framtr\u00e4dande sederande, antikolinerga eller kardiovaskul\u00e4ra bieffekter, vilket har gjort att den anses som s\u00e4rskilt l\u00e4mplig i v\u00e5rden av \u00e4ldre och alkoholister, d\u00e5 s\u00e5dana personer kan vara mer k\u00e4nsliga f\u00f6r bieffekter fr\u00e5n psykotropiska mediciner.[<\/span>5]<\/span><\/a><\/sup>[<\/span>8]<\/span><\/a><\/sup> Nyare resultat indikerar \u00e4ven potentiella antiepileptiska och sm\u00e4rtstillande egenskaper hos Tianeptin, via antingen direkt eller indirekt modulation av adenosin A1-receptorerna (eftersom dessa effekter har funnits kunna blockeras av experimentella antagonister av denna receptor).[<\/span>9]<\/span><\/a><\/sup><\/p>\n

Tianeptin \u00e4r en l\u00e5geffekts men full agonist av de opioida \u03bc-[<\/span>note 1]<\/span><\/a><\/sup> och \u03b4- receptorerna, men inte p\u00e5 \u03ba-receptorerna.<\/p>\n

Opiata \u03bc-agonister inducerar i regel eufori och s\u00e5 har \u00e4ven Tianeptin funnits g\u00f6ra, p\u00e5 doser l\u00e5ngt ut\u00f6ver de som anv\u00e4nds inom v\u00e5rden av patienter.[<\/span>11]<\/span><\/a><\/sup><\/p>\n

Tianeptin uppt\u00e4cktes och patenterades av Franska Nationalinstitutet f\u00f6r Medicin i Paris – Soci\u00e9t\u00e9 de M\u00e9decine de Paris \u2013<\/i> p\u00e5 1960-talet. F\u00f6r tillf\u00e4llet \u00e4r Tianeptin godk\u00e4nd i Frankrike d\u00e4r den tillverkas och marknadsf\u00f6rs av Laboratories Servier SA, men den marknadsf\u00f6rs under licens i ett flertal andra europeiska l\u00e4nder under varunamn som \u201dCoaxil\u201d, s\u00e5v\u00e4l som i Asien (inklusive Singapore) och Latinamerika under namnen \u201dStablon\u201d och \u201dTatinol\u201d men den \u00e4r inte tillg\u00e4nglig p\u00e5 marknaden i Australien, Kanada, Nya Zeeland, Storbritannien eller USA.[<\/span>6]<\/span><\/a><\/sup>[<\/span>12]<\/span><\/a><\/sup><\/p>\n

Ej heller \u00e4r Tianeptin godk\u00e4nt av l\u00e4kemedelsverket i Sverige.<\/p>\n

Depression och \u00e5ngest<\/span><\/h3>\n

Tianeptin visar effekt mot allvarliga depressiva episoder (sv\u00e5r depression<\/a>), j\u00e4mf\u00f6rbar med amitriptylin<\/a>, imipramin<\/a> och fluoxetine<\/a>, men med avsev\u00e4rt f\u00e4rre biverkningar.[14] Det har visat sig vara mer effektivt \u00e4n maprotilin i en grupp personer med samtidig depression och \u00e5ngest.[6] Tianeptin uppvisar ocks\u00e5 betydande \u00e5ngestd\u00e4mpande egenskaper och \u00e4r anv\u00e4ndbart vid behandling av ett spektrum av \u00e5ngestsjukdomar, inklusive paniksyndrom<\/a>, vilket styrks av en studie d\u00e4r personer som fick 35 % CO\u2082<\/a>-gas (karbogen<\/a>) under behandling med paroxetine<\/a> eller tianeptin uppvisade likv\u00e4rdiga panikh\u00e4mmande effekter.[20] Liksom m\u00e5nga antidepressiva (inklusive bupropion<\/a>, selektiva serotonin\u00e5terupptagsh\u00e4mmare<\/a>, serotonin-noradrenalin\u00e5terupptagsh\u00e4mmare<\/a>, moklobemid<\/a> och flera andra) kan det \u00e4ven ha en positiv effekt p\u00e5 kognitionen hos personer med depression-inducerad kognitiv dysfunktion.[21]<\/a> En studie fr\u00e5n 2005 i Egypten visade att tianeptin var effektivt hos m\u00e4n med depression och erektil dysfunktion.[22]<\/a><\/p>\n

Andra anv\u00e4ndningsomr\u00e5den<\/span><\/h3>\n

En klinisk studie som j\u00e4mf\u00f6rde effektivitet och tolerabilitet mellan tianeptin och amitriptylin<\/a> vid behandling av irritabel tarm<\/a> (IBS) visade att tianeptin var minst lika effektivt som amitriptylin och gav f\u00e4rre framtr\u00e4dande biverkningar som muntorrhet och f\u00f6rstoppning.<\/p>\n

Tianeptin har rapporterats vara mycket effektivt mot asthma<\/a>. I augusti 1998 publicerade Dr. Fuad Lechin och kollegor vid Institutet f\u00f6r experimentell medicin p\u00e5 Centraluniversitetet i Venezuela<\/a> i Caracas<\/a> resultaten av en 52-veckors randomiserad kontrollerad studie<\/a> p\u00e5 astmatiska barn; barnen i de grupper som fick tianeptin visade en kraftig minskning i klinisk bed\u00f6mning samt f\u00f6rb\u00e4ttrad lungfunktion. Tv\u00e5 \u00e5r tidigare hade de funnit ett tydligt positivt samband mellan fritt serotonin i plasma<\/a> och astmasv\u00e5righetsgrad hos symtomatiska personer. Eftersom tianeptin var det enda \u00e4mnet som b\u00e5de kunde minska fritt serotonin i plasma och \u00f6ka upptaget i trombocyter, valde de att anv\u00e4nda det f\u00f6r att unders\u00f6ka om s\u00e4nkning av serotoninhalten kunde hj\u00e4lpa. I november 2004 hade tv\u00e5 dubbelblinda placebokontrollerade crossover-studier samt en \u00f6ppen studie med \u00f6ver 25 000 deltagare under mer \u00e4n sju \u00e5rs tid genomf\u00f6rts \u2013 alla visade p\u00e5 effektivitet.<\/p>\n

Tianeptin har \u00e4ven visat sig ha antikonvulsiva<\/a> och sm\u00e4rtlindrande<\/a> egenskaper, och en klinisk studie i Spanien som avslutades i januari 2007 visade att tianeptin \u00e4r effektivt vid behandling av sm\u00e4rta orsakad av fibromyalgi<\/a>. Tianeptin har ocks\u00e5 visat sig vara effektivt med minimala biverkningar vid behandling av uppm\u00e4rksamhetsst\u00f6rning med hyperaktivitet<\/a> (ADHD).[30]<\/p>\n","protected":false},"excerpt":{"rendered":"

Klass:<\/strong> Tianeptine\u00a0 0.20mg<\/p>\n

Ej f\u00f6r konsumtion utan forskningspellets.<\/p>\n

Form:<\/strong> Tablett, Vit rund med kryss<\/p>\n

Inneh\u00e5ll:<\/strong> Tianeptine Sodium<\/p>\n

Den som \u00e4r nyfiken kan l\u00e4sa f\u00f6ljande fr\u00e5n Wikipedia Ref : https:\/\/sv.wikipedia.org\/wiki\/Tianeptin<\/p>\n","protected":false},"featured_media":92,"template":"","meta":[],"product_brand":[],"product_cat":[16],"product_tag":[],"class_list":{"0":"post-6836","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-kemikalier","8":"first","9":"instock","10":"purchasable","11":"product-type-variable","12":"has-default-attributes"},"yoast_head":"\nTianeptin\/e Tabletter 0.20mg | RC-INRIKES.COM<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rc-inrikes.com\/shop\/product\/tianeptin-e-tabletter-0-20mg\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tianeptin\/e Tabletter 0.20mg | RC-INRIKES.COM\" \/>\n<meta property=\"og:description\" content=\"Klass: Tianeptine\u00a0 0.20mg Ej f\u00f6r konsumtion utan forskningspellets. 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