{"id":62,"date":"2019-05-29T18:50:19","date_gmt":"2019-05-29T18:50:19","guid":{"rendered":"https:\/\/rc-inrikes.com\/shop\/?post_type=product&p=62"},"modified":"2025-04-12T17:10:01","modified_gmt":"2025-04-12T17:10:01","slug":"tianeptine-sodium-99-2","status":"publish","type":"product","link":"https:\/\/rc-inrikes.com\/shop\/product\/tianeptine-sodium-99-2\/","title":{"rendered":"Tianeptine Sodium 99.2%"},"content":{"rendered":"

Den som \u00e4r nyfiken kan l\u00e4sa f\u00f6ljande fr\u00e5n Wikipedia Ref : https:\/\/sv.wikipedia.org\/wiki\/Tianeptin<\/a><\/p>\n

Tianeptin<\/b> (varum\u00e4rkena Stablon, Coaxil, Tatinol, Tianeurax och Salymbra) \u00e4r en medicin som anv\u00e4nds prim\u00e4rt i behandlingen av kronisk depression. Den har dock visat p\u00e5 potential som behandling av astma och IBS \u2013 k\u00e4nslig tarm. Kemiskt sett s\u00e5 \u00e4r den n\u00e4ra besl\u00e4ktad med tricykliska antidepressiva<\/a> (TCA), men dess farmakologiska egenskaper \u00e4r n\u00e4rmast helt atypiska i j\u00e4mf\u00f6relse med TCA-preparaten \u2013 nyare forskning tyder p\u00e5 att Tianeptin verkar antidepressivt genom indirekt f\u00f6r\u00e4ndring av glutamaterg aktivitet (p\u00e5 AMPA och NMDA -receptorerna) och genom frig\u00f6relse av BDNF, som i sin tur p\u00e5verkar neuroplasticitet. [<\/span>1]<\/span><\/a><\/sup>[<\/span>2]<\/span><\/a><\/sup>[<\/span>3]<\/span><\/a><\/sup>[<\/span>4]<\/span><\/a><\/sup>[<\/span>5]<\/span><\/a><\/sup>[<\/span>6]<\/span><\/a><\/sup><\/p>\n

Det fullst\u00e4ndiga systematiska namnet<\/a> f\u00f6r substansen \u00e4r 7-[(3-kloro-6-metyl-5,5-dioxo-11H-benzo[c][2,1]benzotiazepin-11-yl)amino]heptanoisk syra.<\/p>\n

Tianeptin har antidepressiva och anxiolytiska (\u00e5ngestd\u00e4mpande) egenskaper[<\/span>7]<\/span><\/a><\/sup> utan n\u00e5gra framtr\u00e4dande sederande, antikolinerga eller kardiovaskul\u00e4ra bieffekter, vilket har gjort att den anses som s\u00e4rskilt l\u00e4mplig i v\u00e5rden av \u00e4ldre och alkoholister, d\u00e5 s\u00e5dana personer kan vara mer k\u00e4nsliga f\u00f6r bieffekter fr\u00e5n psykotropiska mediciner.[<\/span>5]<\/span><\/a><\/sup>[<\/span>8]<\/span><\/a><\/sup> Nyare resultat indikerar \u00e4ven potentiella antiepileptiska och sm\u00e4rtstillande egenskaper hos Tianeptin, via antingen direkt eller indirekt modulation av adenosin A1-receptorerna (eftersom dessa effekter har funnits kunna blockeras av experimentella antagonister av denna receptor).[<\/span>9]<\/span><\/a><\/sup><\/p>\n

Tianeptin \u00e4r en l\u00e5geffekts men full agonist av de opioida \u03bc-[<\/span>note 1]<\/span><\/a><\/sup> och \u03b4- receptorerna, men inte p\u00e5 \u03ba-receptorerna.<\/p>\n

Opiata \u03bc-agonister inducerar i regel eufori och s\u00e5 har \u00e4ven Tianeptin funnits g\u00f6ra, p\u00e5 doser l\u00e5ngt ut\u00f6ver de som anv\u00e4nds inom v\u00e5rden av patienter.[<\/span>11]<\/span><\/a><\/sup><\/p>\n

Tianeptin uppt\u00e4cktes och patenterades av Franska Nationalinstitutet f\u00f6r Medicin i Paris – Soci\u00e9t\u00e9 de M\u00e9decine de Paris \u2013<\/i> p\u00e5 1960-talet. F\u00f6r tillf\u00e4llet \u00e4r Tianeptin godk\u00e4nd i Frankrike d\u00e4r den tillverkas och marknadsf\u00f6rs av Laboratories Servier SA, men den marknadsf\u00f6rs under licens i ett flertal andra europeiska l\u00e4nder under varunamn som \u201dCoaxil\u201d, s\u00e5v\u00e4l som i Asien (inklusive Singapore) och Latinamerika under namnen \u201dStablon\u201d och \u201dTatinol\u201d men den \u00e4r inte tillg\u00e4nglig p\u00e5 marknaden i Australien, Kanada, Nya Zeeland, Storbritannien eller USA.[<\/span>6]<\/span><\/a><\/sup>[<\/span>12]<\/span><\/a><\/sup><\/p>\n

Ej heller \u00e4r Tianeptin godk\u00e4nt av l\u00e4kemedelsverket i Sverige.<\/p>\n

Depression och \u00e5ngest<\/span><\/h3>\n

Tianeptin har visat effekt vid allvarliga depressiva episoder (egentlig depression<\/a>), j\u00e4mf\u00f6rbar med amitriptylin<\/a>, imipramin<\/a> och fluoxetin<\/a>, men med avsev\u00e4rt f\u00e4rre biverkningar. Det har visat sig vara mer effektivt \u00e4n maprotilin<\/a> i en grupp personer med samtidig depression och \u00e5ngest. Tianeptin uppvisar ocks\u00e5 betydande \u00e5ngestd\u00e4mpande egenskaper och \u00e4r anv\u00e4ndbart vid behandling av en rad \u00e5ngestsyndrom, inklusive paniksyndrom<\/a>. Detta har bekr\u00e4ftats i en studie d\u00e4r deltagare som fick 35\u202f% CO\u2082<\/a>-gas (karbogen<\/a>) under behandling med paroxetin<\/a> eller tianeptin uppvisade likv\u00e4rdiga panikblockerande effekter. Liksom m\u00e5nga antidepressiva l\u00e4kemedel (inklusive bupropion<\/a>, selektiva serotonin\u00e5terupptagsh\u00e4mmare<\/a>, serotonin-noradrenalin\u00e5terupptagsh\u00e4mmare<\/a>, moklobemid<\/a> och flera andra) kan tianeptin ocks\u00e5 ha en positiv effekt p\u00e5 kognition hos personer med depression-inducerad kognitiv dysfunktion<\/a>. En studie fr\u00e5n 2005 i Egypten visade att tianeptin var effektivt hos m\u00e4n med depression och erektil dysfunktion<\/a>.<\/p>\n

Tianeptin har visat sig vara effektivt vid depression hos personer med Parkinsons sjukdom, samt vid posttraumatiskt stressyndrom<\/a> (PTSD), d\u00e4r det var lika s\u00e4kert och effektivt som fluoxetin<\/a> och moklobemid<\/a>.<\/p>\n

Andra anv\u00e4ndningsomr\u00e5den<\/span><\/h3>\n

En klinisk studie som j\u00e4mf\u00f6rde effektivitet och tolerabilitet mellan tianeptin och amitriptylin<\/a> vid behandling av irritabel tarm<\/a> (IBS) visade att tianeptin var minst lika effektivt som amitriptylin och orsakade f\u00e4rre framtr\u00e4dande biverkningar som muntorrhet och f\u00f6rstoppning.<\/p>\n

Tianeptin har ocks\u00e5 rapporterats vara mycket effektivt vid astma<\/a>. I augusti 1998 publicerade Dr. Fuad Lechin och kollegor vid Central University of Venezuela<\/a>, Institutet f\u00f6r experimentell medicin i Caracas<\/a>, resultaten av en 52 veckor l\u00e5ng randomiserad kontrollerad studie<\/a> p\u00e5 astmatiska barn; barnen i grupperna som fick tianeptin visade en tydlig f\u00f6rb\u00e4ttring i kliniska bed\u00f6mningar och f\u00f6rb\u00e4ttrad lungfunktion. Tv\u00e5 \u00e5r tidigare hade de funnit ett n\u00e4ra, positivt samband mellan fritt serotonin i plasma<\/a> och astmans sv\u00e5righetsgrad hos symtomatiska personer. Eftersom tianeptin var det enda \u00e4mnet som var k\u00e4nt f\u00f6r att b\u00e5de minska fritt serotonin i plasma och \u00f6ka upptaget i blodpl\u00e4ttar, valde de att testa om en s\u00e4nkning av plasmaserotonin kunde hj\u00e4lpa. Fram till november 2004 hade tv\u00e5 dubbelblinda, placebokontrollerade crossover-studier och en \u00f6ppen studie med \u00f6ver 25\u202f000 personer \u00f6ver mer \u00e4n sju \u00e5r visat positiva resultat.<\/p>\n

Tianeptin har \u00e4ven visat sig ha antikonvulsiva<\/a> och sm\u00e4rtlindrande<\/a> egenskaper, och en klinisk studie i Spanien som avslutades i januari 2007 visade att tianeptin var effektivt vid behandling av sm\u00e4rta vid fibromyalgi<\/a>. Tianeptin har ocks\u00e5 visat effekt med minimala biverkningar vid behandling av ADHD (attention-deficit hyperactivity disorder<\/a>).<\/sup><\/p>\n","protected":false},"excerpt":{"rendered":"

Klass:<\/strong> Tianeptine
\nForm:<\/strong> Vitt pulver, 99.3%
\nInneh\u00e5ll:<\/strong> Tianeptine Sodium -Mild Opiatiska effekter samt mot Depression och \u00e5ngest. Ej f\u00f6r m\u00e4nsklig konsumtion.
\n<\/strong><\/p>\n","protected":false},"featured_media":91,"template":"","meta":[],"product_brand":[],"product_cat":[16],"product_tag":[],"class_list":{"0":"post-62","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-kemikalier","8":"first","9":"instock","10":"purchasable","11":"product-type-variable","12":"has-default-attributes"},"yoast_head":"\nTianeptine Sodium 99.2% | RC-INRIKES.COM<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rc-inrikes.com\/shop\/product\/tianeptine-sodium-99-2\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tianeptine Sodium 99.2% | RC-INRIKES.COM\" \/>\n<meta property=\"og:description\" content=\"Klass: Tianeptine Form: Vitt pulver, 99.3% Inneh\u00e5ll: Tianeptine Sodium -Mild Opiatiska effekter samt mot Depression och \u00e5ngest. 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